Bills vs. Cardinals 2024 Prediction, Odds, Picks - Sep 8

Updated Sep. 8, 2024 12:43 p.m. ET

Data Skrive

The Buffalo Bills (0-0) are considered favorites (-6.5) according to the bookmakers ahead of their game against the Arizona Cardinals (0-0) on September 8, 2024, starting at 1:00 p.m. ET, airing on CBS. The expected point total for the matchup is set at 46.

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Bills vs. Cardinals Odds & Betting Lines

Bills vs Cardinals Betting Information updated as of September 8, 2024, 10:33 a.m. ET.
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds
Bills	-6.5	-115	-105	46	-110	-110

Bills vs. Cardinals Prediction & Pick

Pick ATS: Bills (-6.5)
Pick OU: Under (46)
Prediction: Bills 32 - Cardinals 14

How to Watch Buffalo vs. Arizona

Game Date: Sunday, September 8, 2024
Time: 1:00 p.m. ET
Venue: Highmark Stadium
Location: Orchard Park, New York
TV: CBS
Live Boxscore: FOX Sports

Bills vs. Cardinals Recent Matchups

Buffalo holds a 3-1 record against Arizona in their last four matchups.
Over their last four head-to-head contests, Buffalo has racked up 107 points, while Arizona has accumulated 89.

Buffalo Betting Info

Buffalo went 7-10-0 ATS last season.
The Bills had two wins ATS (2-6) as a 6.5-point favorite or more last season.
Buffalo games went over the point total six out of 17 times last season.
The Bills finished 10-4 in games they were listed as the moneyline favorite last season (winning 71.4% of those games).
Buffalo had a record of 6-2 in games it played as a moneyline favorite with odds of -305 or shorter (75%).
The Bills have a 75.3% chance to win this matchup based on the moneyline's implied probability.

Bills Stats (2023)

Stat	Average (Total)	Rank
Pass yards	244.4 (4,154)	8
Rush yards	130.1 (2,212)	7
Points scored	26.5 (451)	6
Pass yards against	196.6 (3,342)	7
Rush yards against	110.6 (1,880)	15
Points allowed	18.3 (311)	4

Buffalo's Key Players

Offense

Josh Allen threw for 4,306 yards last year (to rank fourth in the NFL), with 29 touchdowns (fifth in the NFL) and 18 interceptions. He completed 66.5% of his attempts while averaging 253.3 yards per game and 7.4 per attempt.
He added 524 yards on the ground, while scoring 15 rushing touchdowns. He averaged 30.8 yards per game and 4.7 per attempt.
James Cook averaged 66 rushing yards per game through 17 games (1,122 total yards to rank fourth in the NFL), while scoring two rushing touchdowns.
Cook added 44 receptions (2.6 per game) for 445 yards (26.2 per game) with four receiving touchdowns. He was targeted 54 times in the passing game.
Curtis Samuel totaled 613 receiving yards and four touchdowns on 62 receptions while being targeted 91 times last season while playing with the Commanders.
Dalton Kincaid was targeted 91 times, resulting in 73 catches for 673 yards .

Defense

Terrel Bernard intercepted three passes and also had143 tackles, 10 TFL, 6.5 sacks, and five passes defended in 2023.
Nicholas Morrow had 93 tackles, 12 TFL, and three sacks for the Eagles.
Taron Johnson had one sack as well as three TFL and 98 tackles in the 2023 season.
Ed Oliver had 9.5 sacks to go with 14 TFL, 51 tackles, and one interception over 16 games.

Arizona Betting Info

Arizona won nine games against the spread last season, failing to cover eight times.
Against the spread, as underdogs of 6.5 points or more, the Cardinals went 4-5 last year.
In Arizona games last season, combined scoring went over the point total 10 times.
Last season, the Cardinals won four out of the 17 games, or 23.5%, in which they were the underdog.
Arizona was 2-7 last season when entering a game as the underdog by +245 or more on the moneyline.
The moneyline for this contest implies a 29.0% chance of a victory for the Cardinals.

Cardinals Stats (2023)

Stat	Average (Total)	Rank
Pass yards	184.9 (3,144)	26
Rush yards	139.1 (2,365)	4
Points scored	19.4 (330)	24
Pass yards against	212.5 (3,613)	13
Rush yards against	143.2 (2,434)	32
Points allowed	26.8 (455)	31

Arizona's Key Players

Offense

Last year in 13 games, James Conner churned out 1,040 yards rushing (sixth in NFL) and scored seven rushing TDs. He averaged 80 yards per game and 5 per carry (sixth in NFL).
In addition to his rushing stats, Conner had 27 catches (on 33 targets) for 165 yards, with two receiving TDs. He averaged 12.7 receiving yards per game.
In eight games, Kyler Murray had 1,799 passing yards, throwing for 10 TDs with five INTs and completing 65.7% of his attempts.
Murray also had three rushing TDs and 244 rushing yards.
In 17 games last season, Trey McBride had 81 catches (4.8 per game on 6.2 targets per game) for 825 yards and three TDs.
Michael Wilson had 38 receptions for 565 yards and three TDs. He averaged 2.9 yards per game in 13 games and was targeted 58 times.

Defense

Jalen Thompson put up one sack to go along with five TFL, 78 tackles, and four interceptions in his 15 games in 2023.
Kyzir White had two sacks to go along with his nine TFL, 90 tackles, and one interception in 11 games.
Dennis Gardeck recorded six sacks and seven TFL and 41 tackles during the 2023 season.
Justin Jones totaled 4.5 sacks plus 10 TFL and 49 tackles for the Bears last season.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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