Bills vs. Colts 2024 Prediction, Odds, Picks - Nov 10

Updated Nov. 10, 2024 12:44 p.m. ET

Data Skrive

The Buffalo Bills (7-2) will be attempting to continue a four-game winning streak against the Indianapolis Colts (4-5). The Bills are the favorites, expected to win by at least a field goal but less than a touchdown (currently -4.5). An over/under of 46.5 points has been set for the matchup.

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Bills vs. Colts Odds & Betting Lines

Bills vs Colts Betting Information updated as of November 10, 2024, 11:33 a.m. ET.
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds
Bills	-4.5	-115	-105	46.5	-112	-108

Bills vs. Colts Prediction & Pick

Pick ATS: Bills (-4.5)
Pick OU: Under (46.5)
Prediction: Bills 26 - Colts 20

How to Watch Buffalo vs. Indianapolis

Game Date: Sunday, November 10, 2024
Time: 1 p.m. ET
Venue: Lucas Oil Stadium
Location: Indianapolis, Indiana
TV: CBS
Live Boxscore: FOX Sports

Bills vs. Colts Recent Matchups

Indianapolis holds a 3-2 record against Buffalo in their last five matchups.
In their last five head-to-head matchups, Indianapolis has tallied 119 points versus Buffalo, while surrendering only 73 points.

Buffalo Betting Info

Against the spread, Buffalo is 5-4-0 this season.
The Bills have covered the spread once this season (1-2 ATS) when playing as at least 4.5-point favorites.
Buffalo games this year have gone over the total in five out of nine opportunities (55.6%).
The Bills have not yet lost when playing as the moneyline favorite, going 6-0 in those matchups this season.
The Bills have an implied win probability, based on the moneyline, of 69.7%.

Bills Stats

Stat	Average (Total)	Rank
Pass yards	216.1 (1,945)	16
Rush yards	119.1 (1,072)	17
Points scored	28.9 (260)	4
Pass yards against	209.9 (1,889)	16
Rush yards against	123.4 (1,111)	15
Points allowed	19.2 (173)	8

Buffalo's Key Players

Offense

Josh Allen has thrown for 2,001 yards (10th in the NFL), 17 touchdowns (fourth in the NFL) and two interceptions this year. He averages 222.3 yards per game and 7.6 per attempt, while completing 64.1% of his attempts.
He has tacked on 211 rushing yards (23.4 per game) and three touchdowns on the ground.
James Cook averages 4.6 yards per carry (18th in the NFL) and 62 yards per game, and has 496 total rushing yards. He has recorded seven rushing TDs this season.
Cook's 22 targets as part of the passing attack have resulted in 19 catches (2.4 per game) for 170 yards (21.3 per game) and one touchdown.
Through nine games played, Keon Coleman is averaging 46.3 yards and 2.4 receptions per game on the way to 417 receiving yards and 22 catches. He's been targeted 36 times, and has three receiving touchdowns.
Khalil Shakir averages 5.3 receptions and 58.9 yards per game, and has 471 total receiving yards and 42 catches. He's gotten 45 total targets, and has caught two touchdown passes.

Defense

On defense, Dorian Williams has 82 tackles and four TFL in 2024.
Gregory Rousseau has 33 tackles, 11 TFL, and 4.5 sacks this season.
Damar Hamlin has recorded 57 tackles, two TFL, and two interceptions this year.
This season, Terrel Bernard has 40 tackles, three TFL, and one interception.

Indianapolis Betting Info

Indianapolis is 7-2-0 against the spread this season.
The Colts have been underdogs by 4.5 points or more two times this year and covered the spread once.
Games involving Indianapolis have hit the over on three occasions this year.
The Colts have been underdogs in six games this season and won two (33.3%) of those contests.
The Colts have a 34.5% chance to win this game based on the implied probability of the moneyline.

Colts Stats

Stat	Average (Total)	Rank
Pass yards	193.7 (1,743)	22
Rush yards	121.3 (1,092)	16
Points scored	20.9 (188)	18
Pass yards against	233.8 (2,104)	26
Rush yards against	149.8 (1,348)	31
Points allowed	21.4 (193)	12

Indianapolis' Key Players

Offense

This year in six games, Jonathan Taylor has racked up 502 rushing yards (leading the Colts) and scored five rushing touchdowns. He averages 83.7 yards per game and 4.8 per attempt (14th in the NFL).
Taylor has also been a part of the receiving game with 100 yards (16.7 per game) on 10 receptions (1.7 per game), while being targeted 16 times. He is still seeking his first receiving touchdown.
In six games, Anthony Richardson has 958 passing yards, while throwing four touchdowns against seven interceptions and completing 44.4% of his passes.
He has added 242 rushing yards (second on the Colts), with one touchdown on the ground (averaging 40.3 yards per game and 5.9 per carry).
Through nine games played this season, Alec Pierce has 19 catches (2.1 receptions per game on 3.7 targets per game) for 435 yards and three receiving touchdowns.
Josh Downs has 411 receiving yards and three touchdowns from 38 receptions after getting 56 targets.

Defense

In 2024, Zaire Franklin has put up 95 tackles, two TFL, and one interception over nine games.
Nick Cross has two interceptions on top of 86 tackles, one TFL, and three passes defended.
E.J. Speed has recorded six TFL and 82 tackles in the 2024 season.
Jaylon Jones has intercepted two passes to go with 59 tackles, three TFL, and nine passes defended.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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