Bills vs. Colts 2024 Prediction, Odds, Picks - Nov 10

Updated Nov. 8, 2024 8:43 p.m. ET

Data Skrive

The Buffalo Bills (7-2) will be trying to extend a four-game winning run against the Indianapolis Colts (4-5). The Bills are the favorites, expected to win by at least a field goal but less than a touchdown (currently -3.5). The over/under for this one is set at 46.5 points.

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Bills vs. Colts Odds & Betting Lines

Bills vs Colts Betting Information updated as of November 8, 2024, 6:33 p.m. ET.
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds
Bills	-3.5	-112	-108	46.5	-108	-112

Bills vs. Colts Prediction & Pick

Pick ATS: Bills (-3.5)
Pick OU: Under (46.5)
Prediction: Bills 26 - Colts 20

How to Watch Buffalo vs. Indianapolis

Game Date: Sunday, November 10, 2024
Time: 1 p.m. ET
Venue: Lucas Oil Stadium
Location: Indianapolis, Indiana
TV: CBS
Live Boxscore: FOX Sports

Bills vs. Colts Recent Matchups

Over their last five meetings, Indianapolis has collected three wins versus Buffalo.
In their last five head-to-head matchups, Indianapolis has racked up 119 points against Buffalo, while allowing only 73 points.

Buffalo Betting Info

Buffalo is 5-4-0 against the spread this year.
The Bills have been favored by 3.5 points or more four times this season, and covered the spread in two of those games.
Buffalo has combined with its opponent to hit the over in 55.6% of its contests this year (five times over nine games with a set point total).
The Bills were the moneyline favorite six times this season, and won each of those games.
The Bills have an implied win probability, based on the moneyline, of 67.2%.

Bills Stats

Stat	Average (Total)	Rank
Pass yards	216.1 (1,945)	16
Rush yards	119.1 (1,072)	17
Points scored	28.9 (260)	4
Pass yards against	209.9 (1,889)	16
Rush yards against	123.4 (1,111)	15
Points allowed	19.2 (173)	8

Buffalo's Key Players

Offense

Josh Allen ranks 10th in the NFL with 2,001 passing yards in nine games this year, averaging 222.3 per game with a 64.1% completion percentage and 17 touchdowns (fourth in the NFL) against two interceptions.
He has added 211 rushing yards (23.4 per game) and three touchdowns on the ground.
James Cook's rushing statline this season includes 496 yards and seven TDs. He's averaging 62.0 yards per game and 4.6 per attempt (18th in the NFL).
Cook has 19 receptions on 22 targets for 170 yards. He has one receiving TD.
In the passing attack, Keon Coleman, has totaled 417 receiving yards and three touchdowns after pulling down 22 balls on 36 targets. Per game, he's averaging 46.3 yards and 2.4 receptions over nine games.
Khalil Shakir has 42 catches for 471 yards and two touchdowns. He's been targeted 45 times in the air attack, and averages 5.3 receptions and 58.9 yards in eight games played.

Defense

Over on defense, Dorian Williams has 82 tackles and 4.0 TFL in 2024. His tackle total leads the Bills and is eighth in the NFL.
Gregory Rousseau has 33 tackles, 11.0 TFL, and 4.5 sacks this season.
Damar Hamlin has put up 57 tackles, 2.0 TFL, and two interceptions this year.
So far this season, Terrel Bernard has 40 tackles, 3.0 TFL, and one interception.

Indianapolis Betting Info

Indianapolis has covered the spread seven times over nine games with a set total.
This season, the Colts have two ATS wins in three games as an underdog of 3.5 points or more.
This season, three Indianapolis games have gone over the point total.
This season, the Colts have been the underdog six times and won two of those games.
The Colts have a 37.0% chance to win this game based on the implied probability of the moneyline.

Colts Stats

Stat	Average (Total)	Rank
Pass yards	193.7 (1,743)	22
Rush yards	121.3 (1,092)	16
Points scored	20.9 (188)	18
Pass yards against	233.8 (2,104)	26
Rush yards against	149.8 (1,348)	31
Points allowed	21.4 (193)	12

Indianapolis' Key Players

Offense

Jonathan Taylor has rushed for five touchdowns this year, and has 502 total rushing yards (83.7 per game and 4.8 per carry).
Taylor's offensive contributions include 10 receptions (1.7 per game) on 16 targets for 100 yards (16.7 per game), but he has not scored a touchdown in the passing game.
Anthony Richardson has 958 passing yards, four touchdowns and seven interceptions. His completion percentage is 44.4% and he averages 159.7 yards per game and 7.2 per attempt.
Richardson also has one rushing touchdown and 242 rushing yards (second on the Colts).
In nine games played this season, Alec Pierce has 19 catches (2.1 receptions per game on 3.7 targets per game) for 435 yards and three receiving touchdowns.
Josh Downs has 38 catches for 411 yards and three receiving touchdowns. He averages 5.4 yards per game in seven games and has been targeted 56 times.

Defense

So far in 2024, Zaire Franklin has amassed 95 tackles, 2.0 TFL, and one interception through nine games.
Nick Cross has 86 tackles, 1.0 TFL, and two interceptions. He is second on the Colts and sixth in the NFL in tackles.
Over the 2024 season, E.J. Speed has 82 tackles and 6.0 TFL through eight games.
Jaylon Jones has intercepted two passes to go with 59 tackles, 3.0 TFL, and nine passes defended.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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