Bills vs. Jaguars 2024 Prediction, Odds, Picks - Sep 23

Updated Sep. 23, 2024 4:43 p.m. ET

Data Skrive

The Buffalo Bills (2-0) are considered favorites (-4.5) according to the point spread ahead of their game versus the Jacksonville Jaguars (0-2) on September 23, 2024, starting at 7:30 p.m. ET, airing on ESPN. The over/under for this one is set at 46.5 points.

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Bills vs. Jaguars Odds & Betting Lines

Bills vs Jaguars Betting Information updated as of September 23, 2024, 4:34 p.m. ET.
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds
Bills	-4.5	-110	-110	46.5	-112	-108

Bills vs. Jaguars Prediction & Pick

Pick ATS: Bills (-4.5)
Pick OU: Under (46.5)
Prediction: Bills 29 - Jaguars 14

How to Watch Buffalo vs. Jacksonville

Game Date: Monday, September 23, 2024
Time: 7:30 p.m. ET
Venue: Highmark Stadium
Location: Orchard Park, New York
TV: ESPN
Live Boxscore: FOX Sports

Bills vs. Jaguars Recent Matchups

Over their last five meetings, Jacksonville has collected three wins versus Buffalo.
In their last five head-to-head matchups, Jacksonville has compiled 86 points versus Buffalo, while giving up only 81 points.

Buffalo Betting Info

This season Buffalo has one win against the spread.
The Bills have been favored by 4.5 points or more this season once, and failed to cover the spread.
Buffalo games this year have hit the over on one of two set point totals (50%).
The Bills have been moneyline favorites one other time this season, a game they won.
The Bills have an implied win probability, based on the moneyline, of 69.2%.

Bills Stats

Stat	Average (Total)	Rank
Pass yards	180.5 (361)	24
Rush yards	119 (238)	15
Points scored	32.5 (65)	12
Pass yards against	179 (358)	11
Rush yards against	131.5 (263)	22
Points allowed	19 (38)	9

Buffalo's Key Players

Offense

Josh Allen has 371 passing yards, three touchdowns and zero interceptions this year. He has completed 73.8% of his passes, averaging 185.5 yards per game and 8.8 per attempt.
He has also rushed for 41 yards (third on the Bills) and added two touchdowns on the ground, while averaging 20.5 rushing yards per game.
James Cook averages 5 yards per carry (15th in the NFL) and 74.5 yards per game, and has 149 total rushing yards. He has recorded two rushing TDs this season.
Cook's four targets in the passing game have resulted in four catches (two per game) for 49 yards (24.5 per game) and one touchdown.
In two games played, Khalil Shakir is averaging 48 yards and four receptions per game on the way to 96 receiving yards and eight catches. He's been targeted eight times, and has one receiving touchdown.
Mack Hollins has 25 receiving yards and one touchdown with two catches on three targets. He's averaging one receptions and 12.5 yards per game.

Defense

Over on the defensive side, Gregory Rousseau has 10 tackles, four TFL, and three sacks in 2024.
Dorian Williams has one TFL and 18 tackles.
Christian Benford has put up one interception (ninth in the NFL) and has added 10 tackles and one pass defended.
Von Miller has four tackles, two TFL, and two sacks.

Jacksonville Betting Info

Jacksonville has covered the spread in a matchup one time this season (1-1-0).
This year, not one Jacksonville's games have hit the over.
The Jaguars lost the only game they've played as the underdog this season.
The implied probability of a win by the Jaguars based on the moneyline is 35.1%.

Jaguars Stats

Stat	Average (Total)	Rank
Pass yards	167.5 (335)	27
Rush yards	127.5 (255)	13
Points scored	15 (30)	32
Pass yards against	245.5 (491)	29
Rush yards against	103 (206)	9
Points allowed	19 (38)	9

Jacksonville's Key Players

Offense

Through two games played this year, Trevor Lawrence has racked up 382 passing yards, with one touchdown against zero interceptions and completing 51% of his passes.
He's added 53 yards on the ground (third on the Jaguars), with zero rushing touchdowns. He's averaging 26.5 yards per game and 17.7 per attempt.
Travis Etienne has 96 rushing yards (leading the Jaguars) and two rushing touchdowns, while averaging 48 yards per game and 3.8 per carry (32nd in the NFL).
Etienne has also picked up 21 receiving yards (10.5 per game) on five catches (2.5 per game). He's been targeted seven times and is still looking for his first receiving touchdown.
So far this season, Brian Thomas Jr. has caught six passes for 141 receiving yards with one touchdown in the passing game. He has been targeted eight total times and is averaging three receptions per game through two games played.
Gabriel Davis has been targeted 10 times, resulting in six catches for 105 yards and zero receiving touchdowns.

Defense

Devin Lloyd has 17 tackles, one TFL, and two passes defended in 2024.
Foyesade Oluokun has 19 tackles, two TFL, one sack, and one pass defended.
Montaric Brown has recorded two TFL and 14 tackles in the 2024 campaign.
Travon Walker's season stats include eight tackles, one TFL, and two sacks in two games. He is fifth on the Jaguars in tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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