Chargers vs. Cardinals 2024 Prediction, Odds, Picks - Oct 21

Chargers vs. Cardinals 2024 Prediction, Odds, Picks - Oct 21

Updated Oct. 21, 2024 8:43 p.m. ET
Data Skrive

The Los Angeles Chargers (3-2) are favored by 1.5 points against the Arizona Cardinals (2-4) on October 21, 2024, starting at 9 p.m. ET, airing on ESPN+. The predicted point total for the matchup is 44.

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Chargers vs. Cardinals Odds & Betting Lines

Chargers vs Cardinals Betting Information updated as of October 21, 2024, 8:33 p.m. ET.
Favorite Spread Favorite Spread Odds Underdog Spread Odds Total Over Total Odds Under Total Odds
Chargers -1.5 -107 -114 44 -112 -108

Chargers vs. Cardinals Prediction & Pick

  • Pick ATS: Chargers (-1.5)
  • Pick OU: Under (44)
  • Prediction: Chargers 22 - Cardinals 19

How to Watch Los Angeles vs. Arizona

  • Game Date: Monday, October 21, 2024
  • Time: 9 p.m. ET
  • Venue: State Farm Stadium
  • Location: Glendale, Arizona
  • TV: ESPN+
  • Live Boxscore: FOX Sports

Chargers vs. Cardinals Recent Matchups

  • In their last five head-to-head bouts, Los Angeles has taken down Arizona four times.
  • Over their last five head-to-head matchups, Los Angeles has scored 155 points, while Arizona has posted 82.

Los Angeles Betting Info

  • Los Angeles has four wins in five games versus the spread this season.
  • The Chargers have an ATS record of 3-0 when playing as at least 1.5-point favorites this season.
  • Los Angeles games this year have hit the over on one of five set point totals (20%).
  • The Chargers have won each of the three games they were favored on the moneyline this season.
  • The Chargers have a 55.0% chance to win this contest, based on the implied probability of the moneyline.

Chargers Stats

Stat Average (Total) Rank
Pass yards 153.2 (766) 30
Rush yards 127.8 (639) 12
Points scored 18.2 (91) 31
Pass yards against 192 (960) 11
Rush yards against 97.2 (486) 6
Points allowed 13.2 (66) 1

Los Angeles' Key Players

Offense

  • J.K. Dobbins' rushing stat line this season includes 438 yards (10th in the NFL) and three TDs. He is averaging 87.6 yards per game and 5.4 per attempt (ninth in the NFL).
  • Justin Herbert has 815 passing yards, six touchdowns and one interception this year. He has completed 64.0% of his attempts, averaging 163.0 yards per game and 6.5 per attempt.
  • Quentin Johnston has three touchdown catches this season, and has 14 receptions for 164 yards on 22 targets, while averaging 2.8 catches and 32.8 yards per game.
  • Ladd McConkey has 219 receiving yards and two touchdowns with 19 catches on 32 targets. He is averaging 3.8 receptions and 43.8 yards per game.

Defense

  • On defense, Denzel Perryman has 1.0 sack (fifth on the Chargers) to go with 2.0 TFL and 36 tackles in 2024.
  • Khalil Mack has 17 tackles, 2.0 TFL, 2.5 sacks, and three passes defended.
  • Daiyan Henley has collected 37 tackles and 2.0 TFL this year. His tackle total leads the Chargers.
  • So far this season, Derwin James has 24 tackles, 3.0 TFL, and one sack.

Arizona Betting Info

  • Arizona is 3-3-0 against the spread this year.
  • So far this season, the Cardinals have been installed as underdogs by a 1.5-point margin or more five times and are 3-2 ATS in those matchups.
  • Arizona's games have finished with a final combined score above the over/under three times this year.
  • This season, the Cardinals have won one out of the four games in which they've been the underdog.
  • Sportsbooks have implied with the moneyline set for this matchup that the Cardinals have a 49.5% chance to win.

Cardinals Stats

Stat Average (Total) Rank
Pass yards 187 (1,122) 24
Rush yards 145.2 (871) 7
Points scored 22.2 (133) 21
Pass yards against 220.3 (1,322) 23
Rush yards against 153 (918) 30
Points allowed 27.2 (163) 29

Arizona's Key Players

Offense

  • In six games played this year, Kyler Murray has racked up 1,186 passing yards, with eight touchdowns against two interceptions and completing 68.2% of his attempts.
  • On the ground, Murray has added one rushing touchdown and 261 rushing yards (second on the Cardinals).
  • James Conner averages 67.2 rushing yards per game over six games (403 total yards), while scoring three rushing touchdowns.
  • Conner has also picked up 88 receiving yards (14.7 per game) on 12 catches (2.0 per game). He's been targeted 15 times and is still looking for his first receiving touchdown.
  • So far this season, Marvin Harrison Jr. has caught 17 passes for 279 receiving yards with four touchdowns through the air (eighth in the NFL). He has been targeted 37 total times and is averaging 2.8 receptions per game through six games played.
  • Michael Wilson has 21 catches for 237 yards and two receiving touchdowns. He averages 3.5 yards per game through six games and has been targeted 30 times.

Defense

  • Budda Baker has 58 tackles, 3.0 TFL, and one pass defended in 2024.
  • Mack Wilson's stat sheet includes one interception as well as 40 tackles, 2.0 TFL, one sack, and three passes defended.
  • Dennis Gardeck has intercepted one pass on top of 17 tackles, 6.0 TFL, three sacks, and two passes defended in the 2024 campaign.
  • Kyzir White's season stats include 45 tackles, 2.0 TFL, and one interception through six games. He is second on the Cardinals in tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Arizona Cardinals
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