Lions vs. Cardinals 2024 Prediction, Odds, Picks - Sep 22

Updated Sep. 22, 2024 12:43 p.m. ET

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The Detroit Lions (1-1) are favored by three points versus the Arizona Cardinals (1-1) on September 22, 2024, starting at 4:25 p.m. ET, airing on FOX. The expected point total for the matchup is set at 51.5.

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Lions vs. Cardinals Odds & Betting Lines

Lions vs. Cardinals Prediction & Pick

• Pick ATS: Cardinals (+3)
  
• Pick OU: Under (51.5)
  
• Prediction: Cardinals 27 - Lions 22

How to Watch Detroit vs. Arizona

• Game Date: Sunday, September 22, 2024
• Time: 4:25 p.m. ET
• Venue: State Farm Stadium
• Location: Glendale, Arizona
• TV: Watch on FOX
• Live Boxscore: FOX Sports

Read More About This Game

• Colts vs. Bears Prediction
• Browns vs. Giants Prediction
• Titans vs. Packers Prediction
• Saints vs. Eagles Prediction
• Steelers vs. Chargers Prediction
• Texans vs. Vikings Prediction
• Buccaneers vs. Broncos Prediction
• Raiders vs. Panthers Prediction
• Seahawks vs. Dolphins Prediction
• 49ers vs. Rams Prediction
• Ravens vs. Cowboys Prediction
• Chiefs vs. Falcons Prediction
• Bills vs. Jaguars Prediction
• Bengals vs. Commanders Prediction

Lions vs. Cardinals Recent Matchups

• In their past five head-to-head matchups, Detroit has won against Arizona four times.
• Over their last five head-to-head matchups, Detroit has scored 126 points, while Arizona has compiled 107.

Detroit Betting Info

• Detroit has one win against the spread in two games this season.
• The Lions have been favored by 3 points or more two times this season, and covered the spread in one of those contests.
• Detroit games this year have not gone over any of two set point totals.
• The Lions have been moneyline favorites in two other games this season, and they split them.
• Looking at this game's moneyline, the Lions' implied win probability is 59.7%.

Lions Stats

Detroit's Key Players

Offense

• Jameson Williams has hauled in 10 passes on 20 targets for 200 total yards (second in the NFL) and one touchdown. He is averaging five catches and 100 yards per game in two games played.
• David Montgomery averages 4.5 yards per carry (23rd in the NFL) and 63 yards per game, and has 126 total rushing yards. He has scored two rushing TDs this season.
• Montgomery's five targets as part of the passing attack have resulted in five catches (2.5 per game) for 37 yards (18.5 per game) and zero touchdowns.
• Through two games, Jahmyr Gibbs has amassed 124 rushing yards, averaging 62 yards per game and scoring one touchdown.
• Gibbs has received 13 targets in the passing game and has 11 catches (5.5 per game) for 56 yards (28 per game) and zero TDs.
• Jared Goff has passed for 524 yards (fifth in the NFL), one touchdown and three interceptions this year. He averages 262 yards per game and 6.3 per attempt, while completing 62.7%.

Defense

• On the defensive side, Aidan Hutchinson has 10 tackles, five TFL, and 5.5 sacks in 2024.
• Brian Branch has picked off one pass (third in the NFL) and added 13 tackles, one TFL, and five passes defended.
• Alex Anzalone has put up 17 tackles and three TFL.
• This season, Jack Campbell has 13 tackles and three TFL.

Arizona Betting Info

• Arizona has covered the spread two times over two games with a set number.
• The Cardinals covered the spread in their only game when underdogs by 3 points or more.
• Arizona games have gone over the total twice this year.
• The Cardinals lost the only game they've played as the underdog this season.
• The implied probability of a win by the Cardinals based on the moneyline is 44.6%.

Cardinals Stats

Arizona's Key Players

Offense

• Kyler Murray is averaging 8.2 passing yards per attempt (seventh in the NFL) and 214 yards per game this year, completing 73.1% of his passes on the way to 428 total yards, four touchdowns (fourth in the NFL) and zero interceptions through two games.
• He's added 116 yards on the ground (second on the Cardinals), with zero rushing touchdowns. He's averaging 58 yards per game and 11.6 per attempt.
• James Conner averages 86 rushing yards per game through two games (172 total yards to rank ninth in the NFL), while scoring two rushing touchdowns.
• Conner has added four receptions (2 per game) for 35 yards (17.5 per game), without a receiving touchdown. He's been targeted five times in the passing game.
• In two games played this season, Marvin Harrison Jr. has five catches (2.5 receptions per game on 5.5 targets per game) for 134 yards and two receiving touchdowns (second in the NFL).
• Trey McBride has 11 catches for 97 yards without a receiving touchdown. He averages 5.5 yards per game through two games and has been targeted 15 times.

Defense

• Dennis Gardeck's 2024 output includes six tackles, four TFL, and three sacks through one game.
• Budda Baker has three TFL and 18 tackles.
• Kyzir White has 18 tackles and one TFL in the 2024 season. He leads the Cardinals in tackles.
• Zaven Collins' season stats include 11 tackles, two TFL, and one sack through two games. He is fourth on the Cardinals in tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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