Lions vs. Cardinals 2024 Prediction, Odds, Picks - Sep 22

Published Sep. 20, 2024 4:43 p.m. ET

Data Skrive

The Detroit Lions (1-1) are favored by three points versus the Arizona Cardinals (1-1) on September 22, 2024, starting at 4:25 p.m. ET, airing on FOX. The expected point total for the game is 51.5.

Keep up with the 2024 NFL season on FOX Sports.

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With many injuries and roster moves, the NFC is wide open as of Week 3. However, Nick Wright remains concerned with its 2023 NFC Championship teams for the San Francisco 49ers 'mini injury bug and the Detroit Lions' clock management, along with Jared Goff's slow start.

Lions vs. Cardinals Odds & Betting Lines

Lions vs Cardinals Betting Information updated as of September 19, 2024, 11:33 a.m. ET.
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds
Lions	-3	-102	-118	51.5	-110	-110

Lions vs. Cardinals Prediction & Pick

Pick ATS: Cardinals (+3)
Pick OU: Under (51.5)
Prediction: Cardinals 27 - Lions 22

How to Watch Detroit vs. Arizona

Game Date: Sunday, September 22, 2024
Time: 4:25 p.m. ET
Venue: State Farm Stadium
Location: Glendale, Arizona
TV: Watch on FOX
Live Boxscore: FOX Sports

Lions vs. Cardinals Recent Matchups

Detroit owns a 4-1 record against Arizona in their last five matchups.
In their last five head-to-head matchups, Detroit has racked up 126 points against Arizona, while allowing only 107 points.

Detroit Betting Info

Detroit has covered the spread on one occasion this season.
The Lions have been favored by 3 points or more two times this season, and covered the spread in one of those matchups.
Detroit games this year have yet to go over the total in two opportunities.
The Lions have been moneyline favorites two other times this season, and they split them.
The implied probability for this matchup, considering the moneyline, gives the Lions a 59.7% chance to win.

Lions Stats

Stat	Average (Total)	Rank
Pass yards	262 (524)	2
Rush yards	151 (302)	8
Points scored	21 (42)	16
Pass yards against	225 (450)	21
Rush yards against	76.5 (153)	3
Points allowed	20 (40)	13

Detroit's Key Players

Offense

Jameson Williams' 200 receiving yards this season (second in the NFL) have come from 10 receptions on 20 targets. He's averaging five catches and 100 yards per game, with one receiving touchdown.
David Montgomery averages 4.5 yards per carry (23rd in the NFL) and 63 yards per game, and has 126 total rushing yards. He has recorded two rushing TDs this season.
Montgomery's five targets as part of the passing attack have turned into five catches (2.5 per game) for 37 yards (18.5 per game) and zero touchdowns.
Jahmyr Gibbs has 124 rushing yards with one touchdown (62 yards per game through two games).
Gibbs has been on the receiving end of 13 targets in the passing game and has 11 catches (5.5 per game) for 56 yards (28 per game) and zero TDs.
Jared Goff has thrown for 524 yards (fifth in the NFL), one touchdown and three interceptions this year. He averages 262 yards per game and 6.3 per attempt, while completing 62.7%.

Defense

Over on defense, Aidan Hutchinson has 10 tackles, five TFL, and 5.5 sacks in 2024.
Brian Branch has 13 tackles, one TFL, and one interception this season. He's third on the Lions in tackles.
Alex Anzalone has recorded 17 tackles and three TFL this year.
This season, Jack Campbell has 13 tackles and three TFL.

Arizona Betting Info

Arizona has covered the spread in each of its two games with a set spread.
The Cardinals covered the spread in their only game when underdogs by 3 points or more.
Games involving Arizona have hit the over twice this year.
The Cardinals lost the only game they've played as the underdog this season.
The bookmakers' moneyline implies a 44.6% chance of a victory for the Cardinals.

Cardinals Stats

Stat	Average (Total)	Rank
Pass yards	202 (404)	16
Rush yards	177.5 (355)	4
Points scored	34.5 (69)	2
Pass yards against	207 (414)	19
Rush yards against	91.5 (183)	9
Points allowed	22 (44)	18

Arizona's Key Players

Offense

Through two games played this year, Kyler Murray has totaled 428 passing yards, with four touchdowns (fourth in the NFL) against zero interceptions and completing 73.1% of his attempts.
Murray has also rushed for 116 yards (second on the Cardinals).
James Conner has scored two rushing touchdowns, while totaling 172 rushing yards (4.6 per attempt and 86 per game).
Conner has also picked up 35 receiving yards (17.5 per game) on four catches (two per game). He's been targeted five times and is still trying for his first receiving touchdown.
Marvin Harrison Jr. has totaled 134 receiving yards and two touchdowns (second in the NFL) on five receptions, while being targeted 11 times on the season.
Trey McBride has 97 receiving yards from 11 receptions after getting 15 targets.

Defense

So far in 2024, Dennis Gardeck has amassed three sacks to go with four TFL and six tackles over one game. He ranks fifth in the NFL in sacks.
Budda Baker has three TFL and 18 tackles over two games.
Kyzir White has 18 tackles and one TFL during the 2024 season.
Zaven Collins has 11 tackles, two TFL, and one sack.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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