The San Francisco 49ers and the Los Angeles Rams hit the field for one of many compelling matchups on the NFL schedule in Week 2.

To pick up an edge ahead of Week 2 in the NFL, see our betting preview below.

Week 2 Betting Lines & Game Info

Philadelphia Eagles vs. Minnesota Vikings

Odds & Prediction

• Spread: Eagles (-6)
• Moneyline: Eagles -252, Vikings +209
• Total: 49 points
• Prediction: Eagles 27, Vikings 14

How to Watch

• Game Date: Thursday, September 14
• Game Time: 8:15 PM ET
• TV Channel: Amazon Prime Video
• Location: Philadelphia, Pennsylvania

Cincinnati Bengals vs. Baltimore Ravens

Odds & Prediction

• Spread: Bengals (-3)
• Moneyline: Bengals -176, Ravens +149
• Total: 45.5 points
• Prediction: Ravens 17, Bengals 14

How to Watch

• Game Date: Sunday, September 17
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: Cincinnati, Ohio

Tampa Bay Buccaneers vs. Chicago Bears

Odds & Prediction

• Spread: Buccaneers (-2.5)
• Moneyline: Buccaneers -133, Bears +113
• Total: 41 points
• Prediction: Buccaneers 29, Bears 19

How to Watch

• Game Date: Sunday, September 17
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Tampa, Florida

Atlanta Falcons vs. Green Bay Packers

Odds & Prediction

• Spread: Falcons (-3)
• Moneyline: Falcons -152, Packers +130
• Total: 40.5 points
• Prediction: Packers 28, Falcons 18

How to Watch

• Game Date: Sunday, September 17
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Atlanta, Georgia

Houston Texans vs. Indianapolis Colts

Odds & Prediction

• Spread: Texans (-1)
• Moneyline: Texans -110, Colts -108
• Total: 40 points
• Prediction: Colts 23, Texans 20

How to Watch

• Game Date: Sunday, September 17
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Houston, Texas

Jacksonville Jaguars vs. Kansas City Chiefs

Odds & Prediction

• Spread: Chiefs (-3)
• Moneyline: Chiefs -169, Jaguars +144
• Total: 50.5 points
• Prediction: Jaguars 27, Chiefs 20

How to Watch

• Game Date: Sunday, September 17
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: Jacksonville, Florida

Buffalo Bills vs. Las Vegas Raiders

Odds & Prediction

• Spread: Bills (-7.5)
• Moneyline: Bills -365, Raiders +287
• Total: 47 points
• Prediction: Bills 23, Raiders 13

How to Watch

• Game Date: Sunday, September 17
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: Orchard Park, New York

Tennessee Titans vs. Los Angeles Chargers

Odds & Prediction

• Spread: Chargers (-2.5)
• Moneyline: Chargers -143, Titans +122
• Total: 45.5 points
• Prediction: Chargers 26, Titans 24

How to Watch

• Game Date: Sunday, September 17
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: Nashville, Tennessee

Detroit Lions vs. Seattle Seahawks

Odds & Prediction

• Spread: Lions (-4.5)
• Moneyline: Lions -220, Seahawks +182
• Total: 47 points
• Prediction: Lions 26, Seahawks 16

How to Watch

• Game Date: Sunday, September 17
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Detroit, Michigan

Arizona Cardinals vs. New York Giants

Odds & Prediction

• Spread: Giants (-4.5)
• Moneyline: Giants -222, Cardinals +183
• Total: 40 points
• Prediction: Giants 22, Cardinals 16

How to Watch

• Game Date: Sunday, September 17
• Game Time: 4:05 PM ET
• TV Channel: Watch Online: FOX
• Location: Glendale, Arizona

Los Angeles Rams vs. San Francisco 49ers

Odds & Prediction

• Spread: 49ers (-7.5)
• Moneyline: 49ers -339, Rams +268
• Total: 45 points
• Prediction: 49ers 24, Rams 16

How to Watch

• Game Date: Sunday, September 17
• Game Time: 4:05 PM ET
• TV Channel: Watch Online: FOX
• Location: Inglewood, California

Dallas Cowboys vs. New York Jets

Odds & Prediction

• Spread: Cowboys (-8.5)
• Moneyline: Cowboys -421, Jets +333
• Total: 38.5 points
• Prediction: Cowboys 32, Jets 7

How to Watch

• Game Date: Sunday, September 17
• Game Time: 4:25 PM ET
• TV Channel: CBS
• Location: Arlington, Texas

Denver Broncos vs. Washington Commanders

Odds & Prediction

• Spread: Broncos (-4)
• Moneyline: Broncos -198, Commanders +167
• Total: 38.5 points
• Prediction: Commanders 18, Broncos 17

How to Watch

• Game Date: Sunday, September 17
• Game Time: 4:25 PM ET
• TV Channel: CBS
• Location: Denver, Colorado

New England Patriots vs. Miami Dolphins

Odds & Prediction

• Spread: Dolphins (-1.5)
• Moneyline: Dolphins -127, Patriots +108
• Total: 46.5 points
• Prediction: Dolphins 32, Patriots 26

How to Watch

• Game Date: Sunday, September 17
• Game Time: 8:20 PM ET
• TV Channel: NBC
• Location: Foxborough, Massachusetts

Carolina Panthers vs. New Orleans Saints

Odds & Prediction

• Spread: Saints (-3)
• Moneyline: Saints -170, Panthers +145
• Total: 39.5 points
• Prediction: Panthers 23, Saints 9

How to Watch

• Game Date: Monday, September 18
• Game Time: 7:15 PM ET
• TV Channel: ESPN
• Location: Charlotte, North Carolina

Pittsburgh Steelers vs. Cleveland Browns

Odds & Prediction

• Spread: Browns (-2)
• Moneyline: Browns -132, Steelers +112
• Total: 38.5 points
• Prediction: Steelers 28, Browns 4

How to Watch

• Game Date: Monday, September 18
• Game Time: 8:15 PM ET
• TV Channel: ABC
• Location: Pittsburgh, Pennsylvania

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