The Week 5 NFL slate includes top teams in play. Among those games is the Jacksonville Jaguars squaring off against the Buffalo Bills.

Read through our odds breakdown for the NFL's Week 5.

Week 5 Betting Lines & Game Info

Washington Commanders vs. Chicago Bears

Odds & Prediction

• Spread: Commanders (-6)
• Moneyline: Commanders -270, Bears +217
• Total: 45 points
• Prediction: Commanders 32, Bears 21

How to Watch

• Game Date: Thursday, October 5
• Game Time: 8:15 PM ET
• TV Channel: Amazon Prime Video
• Location: Landover, Maryland

Buffalo Bills vs. Jacksonville Jaguars

Odds & Prediction

• Spread: Bills (-5)
• Moneyline: Bills -242, Jaguars +198
• Total: 48.5 points
• Prediction: Bills 30, Jaguars 14

How to Watch

• Game Date: Sunday, October 8
• Game Time: 9:30 AM ET
• TV Channel: NFL Network
• Location: London, United Kingdom

Indianapolis Colts vs. Tennessee Titans

Odds & Prediction

• Spread: Titans (-2.5)
• Moneyline: Titans -143, Colts +120
• Total: 43.5 points
• Prediction: Colts 31, Titans 11

How to Watch

• Game Date: Sunday, October 8
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: Indianapolis, Indiana

Detroit Lions vs. Carolina Panthers

Odds & Prediction

• Spread: Lions (-9)
• Moneyline: Lions -476, Panthers +353
• Total: 43.5 points
• Prediction: Lions 36, Panthers 9

How to Watch

• Game Date: Sunday, October 8
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Detroit, Michigan

Atlanta Falcons vs. Houston Texans

Odds & Prediction

• Spread: Falcons (-2.5)
• Moneyline: Falcons -140, Texans +118
• Total: 42 points
• Prediction: Texans 24, Falcons 15

How to Watch

• Game Date: Sunday, October 8
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Atlanta, Georgia

New England Patriots vs. New Orleans Saints

Odds & Prediction

• Spread: Patriots (-2)
• Moneyline: Patriots -129, Saints +109
• Total: 38.5 points
• Prediction: Patriots 22, Saints 15

How to Watch

• Game Date: Sunday, October 8
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: Foxborough, Massachusetts

Miami Dolphins vs. New York Giants

Odds & Prediction

• Spread: Dolphins (-13)
• Moneyline: Dolphins -779, Giants +538
• Total: 47.5 points
• Prediction: Dolphins 37, Giants 18

How to Watch

• Game Date: Sunday, October 8
• Game Time: 1:00 PM ET
• TV Channel: Watch Online: FOX
• Location: Miami Gardens, Florida

Pittsburgh Steelers vs. Baltimore Ravens

Odds & Prediction

• Spread: Ravens (-4.5)
• Moneyline: Ravens -225, Steelers +183
• Total: 38.5 points
• Prediction: Ravens 27, Steelers 13

How to Watch

• Game Date: Sunday, October 8
• Game Time: 1:00 PM ET
• TV Channel: CBS
• Location: Pittsburgh, Pennsylvania

Los Angeles Rams vs. Philadelphia Eagles

Odds & Prediction

• Spread: Eagles (-3.5)
• Moneyline: Eagles -195, Rams +164
• Total: 50.5 points
• Prediction: Rams 30, Eagles 19

How to Watch

• Game Date: Sunday, October 8
• Game Time: 4:05 PM ET
• TV Channel: Watch Online: FOX
• Location: Inglewood, California

Arizona Cardinals vs. Cincinnati Bengals

Odds & Prediction

• Spread: Bengals (-3)
• Moneyline: Bengals -169, Cardinals +142
• Total: 45 points
• Prediction: Cardinals 23, Bengals 18

How to Watch

• Game Date: Sunday, October 8
• Game Time: 4:05 PM ET
• TV Channel: Watch Online: FOX
• Location: Glendale, Arizona

Minnesota Vikings vs. Kansas City Chiefs

Odds & Prediction

• Spread: Chiefs (-3.5)
• Moneyline: Chiefs -184, Vikings +155
• Total: 52.5 points
• Prediction: Chiefs 28, Vikings 15

How to Watch

• Game Date: Sunday, October 8
• Game Time: 4:25 PM ET
• TV Channel: CBS
• Location: Minneapolis, Minnesota

Denver Broncos vs. New York Jets

Odds & Prediction

• Spread: Broncos (-2)
• Moneyline: Broncos -135, Jets +114
• Total: 42.5 points
• Prediction: Jets 28, Broncos 21

How to Watch

• Game Date: Sunday, October 8
• Game Time: 4:25 PM ET
• TV Channel: CBS
• Location: Denver, Colorado

San Francisco 49ers vs. Dallas Cowboys

Odds & Prediction

• Spread: 49ers (-3.5)
• Moneyline: 49ers -183, Cowboys +155
• Total: 45 points
• Prediction: 49ers 26, Cowboys 17

How to Watch

• Game Date: Sunday, October 8
• Game Time: 8:20 PM ET
• TV Channel: NBC
• Location: Santa Clara, California

Las Vegas Raiders vs. Green Bay Packers

Odds & Prediction

• Spread: Raiders (-2)
• Moneyline: Raiders -129, Packers +109
• Total: 45 points
• Prediction: Packers 27, Raiders 18

How to Watch

• Game Date: Monday, October 9
• Game Time: 8:15 PM ET
• TV Channel: ABC/ESPN
• Location: Paradise, Nevada

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