The Biggest NFL Upsets in Week 15 - 2024

Updated Dec. 19, 2024 6:34 p.m. ET

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Looking for upsets? More than one team beat the odds in Week 15 of the 2024 NFL season. Read more about those underdogs who came out on top below.

Read more about last week's NFL games on FOX Sports!

NFL Week 15's Biggest Upsets

Buccaneers 40, Chargers 17

• Spread: Chargers -3
• Total: Over (45.5)
• Moneyline: Chargers -160, Buccaneers +135

Rams 12, 49ers 6

• Spread: 49ers -3
• Total: Under (49)
• Moneyline: 49ers -150, Rams +125

Bills 48, Lions 42

• Spread: Lions -2.5
• Total: Over (55.5)
• Moneyline: Lions -140, Bills +120

Cowboys 30, Panthers 14

• Spread: Panthers -2.5
• Total: Over (42.5)
• Moneyline: Panthers -145, Cowboys +120

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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