Louisville vs. Nebraska Prediction, Odds, Picks – Women's Basketball NCAA Tournament First Round 2025

Updated Mar. 21, 2025 2:02 p.m. ET

Data Skrive

The 10th-seeded Nebraska Cornhuskers (21-11) will try to pull off a first-round NCAA Tournament upset against the No. 7 seed Louisville Cardinals (21-10) on Friday at Ed and Rae Schollmaier Arena. The matchup starts at 6 p.m. ET on ESPN. Nebraska is a 2.5-point underdog in the game. Here's what you need to know before filling out your brackets for this 7-10 matchup. The matchup has an over/under of 145.5.

NCAAW BK

NCAA TOURNMENT - FIRST ROUND

Louisville Cardinals LOU

Nebraska Cornhuskers NEB

FINAL

LOU -1.5 UNDER 145.5

Louisville vs. Nebraska Game Info

Game day: Friday, March 21, 2025
Game time: 6 p.m. ET
TV channel: ESPN
Follow this game live on FOX Sports

Louisville vs. Nebraska Odds

Cardinals vs Cornhuskers Betting Information
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds	Favorite Moneyline	Underdog Moneyline
Cardinals	-2.5	-109	-125	145.5	-110	-110	-130	+110

Louisville vs. Nebraska Prediction

Computer Pick ATS: Nebraska (+2.5)
Computer Pick OU: Under (145.5)
Computer Prediction: Louisville 72, Nebraska 70

Learn more about the Louisville Cardinals vs. the Nebraska Cornhuskers game on FOX Sports!

Louisville Betting Insights

The Cardinals have covered the spread 13 times in 26 games.
Against the spread as 2.5-point favorites or more, Louisville is 6-6.
Out of 26 Cardinals games so far this season, 12 have gone over the total.
Louisville has entered the game as moneyline favorites 12 times this season and won 10, or 83.3%, of those games.
The Cardinals have entered 10 games this season favored by -130 or more and are 9-1 in those contests.

Nebraska Betting Insights

The Cornhuskers have 14 wins in 28 games against the spread this year.
Nebraska's ATS record as a 2.5-point underdog or more is 5-7.
Out of 28 Cornhuskers games so far this season, 18 have hit the over.
Nebraska has won in four, or 30.8%, of the 13 contests it has been named as the moneyline underdog this year.
This year, the Cornhuskers have won three of 12 games when listed as at least +110 or worse on the moneyline.

Louisville's Top Performers

Louisville Leaders | Last 10 Games
Name	PTS	REB	ASST	STL	BLK	3PM
Jayda Curry	13.2	3.1	2.6	2.3	0	1.7
Tajianna Roberts	13.3	4.3	2.4	1.4	0	1.8
Olivia Cochran	10	7.3	0.8	0.6	0.1	0.1
Ja'Leah Williams	8.1	3.8	2	1.4	0	0
Nyla Harris	6.6	5.3	0.7	0.5	0.3	0

Nebraska's Top Performers

Nebraska Leaders | Last 10 Games
Name	PTS	REB	ASST	STL	BLK	3PM
Alexis Markowski	20.7	8.7	1	0.5	1.4	1.5
Britt Prince	10.3	1.9	4.2	0.7	0.4	1.2
Logan Nissley	7.4	4	3.2	1.2	0.1	1.9
Jessica Petrie	7.6	5.7	1.8	0.1	1	0.7
Alberte Rimdal	11.3	1.3	2.5	0.5	0	1.3