College Football

Iowa State vs. Houston Prediction, Odds, Expert Pick

Updated Sep. 26, 2024 4:16 p.m. ET

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The Houston Cougars (1-3) are 14.5-point underdogs in a home Big 12 matchup against the No. 18 Iowa State Cyclones (3-0) on Saturday, September 28, 2024 at John O'Quinn Field at TDECU Stadium. The total has been set at 43.5 points for this matchup.

Last time around, the Cyclones defeated the Arkansas State Red Wolves, with 52-7 being the final score. Last time out, the Cougars fell to the Cincinnati Bearcats, with 34-0 being the final score.

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Iowa State vs. Houston Game Information & Odds

• When: Saturday, September 28, 2024 at 7:00 p.m. ET
• Location: John O'Quinn Field at TDECU Stadium in Houston, Texas
• TV: Fox Sports 1
• Live Box Score on FOX Sports

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Iowa State vs. Houston Prediction

• Pick ATS: Houston (+14.5)  
• Pick OU: Under (43.5) 
• Prediction: Iowa State 24, Houston 17

Predictions are made by the Data Skrive betting model.

Learn more about the Iowa State Cyclones vs. the Houston Cougars game on FOX Sports!

Pick by FOX Sports Betting Analyst Chris Fallica:

The Cyclones put up their best offensive performance of the young season last week, running and passing for over 230 each in a 52-7 rout of Arkansas State. This was the same Arkansas State that lost 28-18 at Michigan the week before. Still, Houston’s defense hasn’t been terrible this year, and off a shutout loss at Cincinnati, I’d expect this Willie Fritz team to put up a bit more of a fight. 

PICK: Houston (+14.5) to lose by fewer than 14.5 points, or win outright

Iowa State vs. Houston Betting Insights

• Per the spread and over/under, the implied score for the matchup is Cyclones 29, Cougars 14.
• The Cyclones have an 87.0% chance to win this game per the moneyline's implied probability. The Cougars have a 17.7% implied probability.
• Iowa State has covered twice in two games with a spread this season.
• Houston has covered twice in four games with a spread this season.

Iowa State vs. Houston: 2024 Stats Comparison

Iowa State 2024 Key Players

Houston 2024 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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CFB - Iowa State Cyclones vs. Houston Cougars - 09/28/2024

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