National Football League

NFL odds: How to bet Broncos vs. Browns, point spread, more

Updated Oct. 21, 2021 1:38 p.m. ET

The task for the Cleveland Browns against the Denver Broncos just got more difficult.

Here's everything you need to know about the NFL odds on Thursday's matchup between the Broncos and Browns — the point spread, moneyline, and total over/under (with all NFL odds via FOX Bet).

Cleveland is dealing with multiple injuries as it listed 20 players on Monday's injury report, twice as many as Denver.

The key one is Browns quarterback Baker Mayfield, who was ruled out Wednesday after he aggravated the partially torn labrum Sunday he injured in his left shoulder Sept. 19. Mayfield said the initial injury was a complete tear of the labrum. He could return as soon as Oct. 31 against the Steelers.

Mayfield is 116-for-173 passing (67.1 percent) for 1,474 yards, six touchdowns, three interceptions, and a 97.8 passer rating this season.

Case Keenum is expected to start at quarterback for the Browns.

The Browns also have injury issues at running back. Already without Nick Chubb, the Browns lost Kareem Hunt to a leg injury during the fourth quarter Sunday. Chubb has been ruled out of the Broncos game, and Hunt was placed on the injured reserve.

Cleveland activated running back John Kelly to join D'Ernest Johnson and Demetric Felton in the backfield. Johnson has run for 11 yards on three carries, while Felton has caught eight of nine targets for 90 yards and a touchdown.

Also placed on IR was Browns linebacker Jeremiah Owusu-Koramoah, which means he and Hunt will miss at least three games.

On the other side, the Broncos are expected to start Teddy Bridgewater at quarterback despite suffering a foot injury Sunday against the Raiders. Bridgewater threw three interceptions, lost a fumble, was sacked five times, and suffered 17 hits against the Raiders.

Bridgewater is 139-for-198 passing (70.2 percent) for 1,514 yards with 10 touchdowns, four interceptions, and a 100.9 passer rating this season.

Denver holds a 24-6 record in the all-time series against the Browns, winning 12 of the past 13 contests.

Both teams are coming off home losses. Arizona won at Cleveland 37-14, and the Raiders beat Denver 34-24.

The Browns have lost two consecutive games, the Broncos have lost three in a row.

Cleveland's Myles Garrett leads the NFL in sacks with 8.0, which could cause problems for Bridgewater in this contest.

Team Trends

The Browns are 7-3 against the spread (ATS) in their past 10 Thursday games.

The over is 4-1 in the Broncos' past five games following a straight-up loss.

DENVER BRONCOS @ CLEVELAND BROWNS (8:20 p.m. ET Thursday, FOX)

Point spread: Browns -2 (favored to win by more than 2 points; otherwise Broncos cover)
Moneyline: Browns -125 favorites to win (bet $10 to win $18 total); Broncos +105 underdogs to win (bet $10 to win $20.50)
Total scoring over/under: 41.5 points scored by both teams combined

Pick via FOX Sports' Geoff Schwartz: "I will take the Case Keenum under passing yards in the Thursday night contest. The Browns are down multiple wide receivers, offensive lineman and running backs. This will be a controlled game plan of running the ball and limiting Keenum's passing attempts. There's also the wind factor.

"The Broncos defense ranks third in the NFL at limiting big plays as well. The Browns just need to get out of this game with a win and nothing more. Expect them to game plan this way."

THE PICK: Case Keenum under 224.5 yards passing (at FOX Bet) against the Broncos

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