National Football League

NFL odds Week 3: How to bet Rams-Cardinals

Updated Sep. 23, 2022 1:13 p.m. ET

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Los Angeles looks to continue its recent dominance when the Rams travel east to play at the Arizona Cardinals on Sunday (4:25 p.m. ET on FOX)

The Rams lead the all-time series 47-29-2, winning 10 of the past 11 meetings against the Cardinals.

Here's everything you need from a betting perspective for the Rams-Cardinals game, from the point spread, moneyline, total over/under and expert pick (odds via FOX Bet):

Kyler Murray leads Cardinals to wild OT win vs. Raiders in Week 2 | UNDISPUTED

Kyler Murray and the Arizona Cardinals were down 20-0 at halftime to the Las Vegas Raiders before they stormed back to win.

RELATED: Sportsbooks win big in Week 2

Rams @ Cardinals (4:25 p.m. ET Sunday, FOX)

Point spread: Rams -3.5 (Rams favored to win by more than 3.5 points, otherwise Cardinals cover)
Moneyline: Rams -189 favorites to win (bet $10 to win $15.29 total); Cardinals +145 underdogs to win (bet $10 to win $24.50 total)
Total scoring over/under: 48.5 points scored by both teams combined

The Rams are 11-3 against the spread (ATS) and 11-3 straight up (SU) against the Cardinals since 2015, with the over/under (O/U) being 7-7.

The Rams are 18-12 ATS and 19-11 SU against NFC West opponents under coach Sean McVay since 2017, with the under in the O/U hitting in 16 of those games.

The Rams are 10-5 ATS and 10-5 SU on the road against NFC West opponents under McVay, with the over hitting in eight of those games.

The Cardinals have lost seven in a row at home against the Rams, last beating them 31-14 on Nov. 9, 2014, when the Rams were in St. Louis.

The Cardinals are 5-5 ATS and 3-6-1 SU as home underdogs under coach Kliff Kingsbury since 2019, with the over hitting seven times.

The Cardinals are 19-9-1 ATS and 15-13-1 SU as underdogs under Kingsbury, with the O/U going 14-14-1. 

Pick by FOX Sports Betting Analyst Geoff Schwartz:

Two underwhelming teams facing off in the desert.  

The Rams are 1-1, but had to fight off a feisty Falcons team that was down 31-10 early in the fourth yet were driving to take the lead in the final two minutes before losing 31-25.   

Arizona got smoked by the Chiefs in Week 1 and needed a historic overtime comeback to beat the Raiders after heading into halftime down 20-0.  

After two weeks, the Cardinals and Rams are ranked 28th and 29th, respectively, in team efficiency, with the Cardinals being weighed down with a 30th ranked defense and the Rams having the 32nd ranked special teams.  

When two teams appear to be equal on paper, I grab the points, especially when I get the three plus the hook. There’s some worry with this wager because Sean McVay’s Rams have dominated the Cardinals, going 10-1 straight up.   

However, this number for the Cardinals is too juicy not to wager on.  

Pick: Arizona (+3.5 at FOX Bet) to lose by fewer than 3.5 points (or win outright)

Are you ready for the NFL season? If so, head over to FOX Bet for all your wagers.

Download the FOX Super 6 app for your chance to win thousands of dollars on the biggest sporting events each and every week! Just make your picks and you could win the grand prize. Download and play today!

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NFL - Los Angeles Rams vs. Arizona Cardinals - 09/25/2022

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Geoff Schwartz