National Football League

NFL odds Week 5: How to bet Steelers-Bills, pick

Updated Oct. 8, 2022 12:19 p.m. ET

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The Kenny Pickett era is now as the Pittsburgh Steelers (1-3) play at the Buffalo Bills (3-1) in an AFC interdivisional contest Sunday.

Pickett, the No. 20 pick in April's draft, is expected to make his first NFL start in place of Mitch Trubisky, who played in six games as the backup quarterback last season for the Bills. Pickett made his pro debut in Sunday's 24-20 loss to the New York Jets and was 10-for-13 passing (76.9%) for 120 yards, no touchdowns and three interceptions. 

Here's everything you need from a betting perspective on the Steelers-Bills game, from the point spread, moneyline, total over/under and expert pick (odds via FOX Bet):

Steelers expected to move forward with Kenny Pickett as starting QB | SPEAK

The Pittsburgh Steelers are reportedly sticking with Kenny Pickett as the team's starting QB moving forward.

RELATED: Pickett gets starting nod

Steelers @ Bills (1 p.m. ET Sunday, CBS)

Point spread: Bills -14 (Bills favored to win by more than 14 points, otherwise Steelers cover)
Moneyline: Bills -909 favorites to win (bet $10 to win $11.10 total); Steelers +500 underdogs to win (bet $10 to win $60 total)
Total scoring over/under: 45.5 points scored by both teams combined

Pick via Gambling Analyst Sam Panayotovich:

Thank you, FOX Bet, for dealing this total at 47.5 (currently 46.5).

It’s one of the few shops in the entire world that isn’t down to a flat 47, and I think you should grab under 47.5 while it’s still available. Steelers rookie quarterback Kenny Pickett is set to make his first NFL start, and I’m skeptical about his chances to put up lots of points here.

When it comes to the Bills, Josh Allen naturally gets most of the credit, but Sean McDermott’s defense is allowing only 14.5 points per game against teams like the Dolphins, Rams and Ravens. Expect Buffalo to run the rock and melt the clock for the majority of the second half.

This feels like a 27-13 final.

PICK: Under 47.5 points (at time of pick) scored by both teams combined at FOX Bet

Are you ready for the NFL season? If so, head over to FOX Bet for all your wagers.

Download the FOX Super 6 app for your chance to win thousands of dollars on the biggest sporting events each and every week! Just make your picks and you could win the grand prize. Download and play today!

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NFL - Pittsburgh Steelers vs. Buffalo Bills - 10/09/2022

Pittsburgh Steelers

Buffalo Bills

Mitchell Trubisky

Kenny Pickett

Josh Allen

Sam Panayotovich