National Football League

NFL odds Week 16: How to bet Bills-Bears

Published Dec. 22, 2022 2:30 p.m. ET

The Buffalo Bills are heading to Illinois to take on the Chicago Bears in a Week 16 NFL matchup.

The Bills defeated the Miami Dolphins in Week 15, while the Bears were tamed by the Philadelphia Eagles.

Here's everything you need from a betting perspective on the Bills-Bears game, from the point spread, moneyline, total Over/Under and expert pick (odds via FOX Bet).

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RELATED: Week 16 lines

Bills at Bears (1 p.m. ET Saturday, CBS)

Point spread: Bills -8.5 (Bills favored to win by more than 8.5 points, otherwise Bears cover)
Moneyline: Bills -400 favorites to win (bet $10 to win $12.50 total); Bears +280 underdogs to win (bet $10 to win $38 total)
Total scoring Over/Under: 40.5 points scored by both teams combined

Pick via Gambling Analyst Sam Panayotovich:

Ten degrees and 20 mile-per-hour winds.

That’s the weather forecast this Saturday at Soldier Field for the Bears and Bills. And that, of course, is on the heels of a potential blizzard that’ll rock Chicago all day Thursday and Friday. Snow isn’t necessarily a big deal for football totals, but wind and frigid temps certainly move the meter.

Bills quarterback Josh Allen has a rocket arm, but I wish him the best trying to rifle high-velocity spirals through that Soldier Field wind. Expect the passing game to be non-existent and the defenses to crowd the box. At the end of the day, these are just miserable conditions for offensive fireworks.

This game could easily be 20-10.

PICK: Under 40.5 points scored by both teams combined at FOX Bet

Are you ready to make an NFL bet? If so, head over to FOX Bet for all your wagers.

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